处方抗真菌药物 - JUBLIA 10%

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Brand Name:JUBLIA 10%
Chemical Name:EFINACONAZOLE 10%

Jublia（依芬那唑 10% w/w 外用溶液）是一种处方抗真菌药物，用于治疗甲癣（趾甲真菌感染）。其作用机制是抑制真菌细胞膜的重要组成部分——麦角甾醇的生成，从而导致真菌死亡。

关键信息

适应症：Jublia 适用于局部治疗由红色毛癣菌和须癣毛癣菌引起的轻度至中度趾甲真菌感染。

用法用量：每日一次，使用内置刷头涂抹于患趾甲及其周围皮肤。为达到最佳疗效，应覆盖整个甲板、趾甲周围的皮肤褶皱、甲床以及甲尖的下表面。

疗程：即使症状提前消失，通常也需每日一次，持续 48 周（约 11 个月）。

供应情况：Jublia 为品牌药，需凭处方购买。目前尚无仿制药。

生产商：该药物由博士伦（Bausch Health，原名 Valeant）公司销售。

重要注意事项

仅限外用：Jublia 仅供外用于趾甲及周围皮肤；不可口服、用于眼部、鼻部、唇部或阴道内。

易燃：本品含有酒精，易燃。请远离热源和明火。

副作用：常见副作用包括用药部位反应，例如皮炎、发红、瘙痒、灼热感、疼痛或嵌甲。

指甲油：使用 Jublia 期间使用指甲油或其他美甲产品的影响尚未评估，因此治疗期间应避免使用此类产品。

儿童用药：本品对 6 岁及以上患者的安全性和有效性已得到证实，但尚未证实对 6 岁以下儿童有效。

欲了解完整信息，请参阅美国食品药品监督管理局 (FDA) 批准的处方信息或咨询医疗保健专业人员。

Jublia (efinaconazole 10% w/w topical solution) is a prescription antifungal medication used to treat onychomycosis (fungal infections of the toenails). It works by inhibiting the production of ergosterol, a vital component of fungal cell membranes, which causes the fungi to die.

Key Information

• Indications: Jublia is indicated for the topical treatment of mild to moderate fungal toenail infections caused by Trichophyton rubrum and *Trichophyton mentagrophytes.
• Application: It is applied once daily to the affected toenails and surrounding skin using a built-in brush applicator. For best results, the entire nail plate, the skin folds around the nail, the nail bed, and the undersurface of the nail tip should be covered.
• Treatment Duration: The typical course of treatment is once daily for 48 weeks (approximately 11 months), even if symptoms clear up earlier.
• Availability: Jublia is a brand-name, prescription-only medication. There is currently no generic version available.
• Manufacturer: The medication is marketed by Bausch Health (formerly Valeant).
  

Important Considerations

• For External Use Only: Jublia is strictly for topical use on toenails and adjacent skin; it is not for oral, eye, nose, lip, or intravaginal use.
• Flammable: The solution contains alcohol and is flammable. Keep it away from heat and open flames.
• Side Effects: Common side effects include application site reactions such as dermatitis, redness, itching, burning, pain, or ingrown toenails.
• Nail Polish: The effect of using nail polish or other cosmetic nail products while using Jublia has not been evaluated, so their use should be avoided during treatment.
• Pediatric Use: Safety and effectiveness have been established for patients 6 years of age and older, but not for children under 6 years old.
  

For complete information, refer to the FDA-approved prescribing information or consult a healthcare professional.